A new method for peptide synthesis in the N→C direction: Amide assembly through silver-promoted reaction of thioamides
The Ag(i)-promoted coupling of amino acids and peptides with amino ester thioamides generates peptide imides without epimerisation. The peptide imides undergo regioselective hydrolysis under mild conditions to generate native peptides. This method was employed to prepare the pentapeptide thymopentin in the N→C direction, in high yield and purity.
Pourvali, Aysa,Cochrane, James R.,Hutton, Craig A.
SYNTHETIC APPROACHES FOR THYMOPENTIN (TP-5) USING THE "IN SITU" SILYLATION STRATEGY WITH TRIMETHYLSILYL CYANIDE
The synthesis of the pentapeptide TP-5 has been considered as a test case for the "in situ" silylating strategy, using trimethylsilyl cyanide, because of the nature of the involved residues.Thus orthogonal lateral protections for Arg, Lys and Asp are need
Becu, Fr.,Becu, Chr.,Anteunis, M. J. O.
p. 15 - 23
(2007/10/02)
More Articles about upstream products of 132903-67-4