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CAS

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1329616-37-6

(S)-(+)-CaMptothecin-d5, also known as Labelled (S)-(-)-Camptothecin (C175150), is an antitumor alkaloid with a unique mechanism of action. It is characterized by its ability to bind irreversibly to the DNA-topoisomerase I complex, which inhibits the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. This property makes it a potent cytotoxic antitumor agent.

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  • 1329616-37-6 Structure

  • Basic information

    1. Product Name: (S)-(+)-CaMptothecin-d5
    2. Synonyms: (S)-(+)-CaMptothecin-d5;(S)-4-(Ethyl-d5)-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
    3. CAS NO:1329616-37-6
    4. Molecular Formula: C20H16N2O4
    5. Molecular Weight: 348.35204
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
    8. Mol File: 1329616-37-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-(+)-CaMptothecin-d5(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-(+)-CaMptothecin-d5(1329616-37-6)
    11. EPA Substance Registry System: (S)-(+)-CaMptothecin-d5(1329616-37-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1329616-37-6(Hazardous Substances Data)

1329616-37-6 Usage

Uses

Used in Pharmaceutical Industry:
(S)-(+)-CaMptothecin-d5 is used as an antitumor agent for its cytotoxic properties against cancer cells. It is particularly effective in targeting and inhibiting the activity of topoisomerase I, a crucial enzyme involved in DNA replication and transcription. This inhibition leads to the prevention of cancer cell proliferation and the induction of cell death, making it a valuable component in the development of anticancer drugs.
Additionally, (S)-(+)-CaMptothecin-d5 can be used as a research tool in the study of topoisomerase I and its role in cancer biology. Its unique binding properties allow researchers to investigate the mechanisms of action and potential applications in cancer therapy, as well as to develop new drugs with improved efficacy and reduced side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 1329616-37-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,2,9,6,1 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1329616-37:
(9*1)+(8*3)+(7*2)+(6*9)+(5*6)+(4*1)+(3*6)+(2*3)+(1*7)=166
166 % 10 = 6
So 1329616-37-6 is a valid CAS Registry Number.

1329616-37-6Upstream product

1329616-37-6Downstream Products

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