Rational Design of a Near-infrared Fluorescence Probe for Ca2+ Based on Phosphorus-substituted Rhodamines Utilizing Photoinduced Electron Transfer
Fluorescence imaging in the near-infrared (NIR) region (650–900 nm) is useful for bioimaging because background autofluorescence is low and tissue penetration is high in this range. In addition, NIR fluorescence is useful as a complementary color window t
PROBLEM TO BE SOLVED: To provide a novel near-infrared fluorescent Ca2+ probe showing a fluorescence rise higher than that of conventional one. SOLUTION: The present invention provides a P rhodamine compound having a calcium ion scavenging grou
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(2018/07/28)
Development of a far-red to near-infrared fluorescence probe for calcium ion and its application to multicolor neuronal imaging
To improve optical imaging of Ca2+ and to make available a distinct color window for multicolor imaging, we designed and synthesized CaSiR-1, a far-red to near-infrared fluorescence probe for Ca2+, using Si-rhodamine (SiR) as the flu