- A facile transformation of the δ-hydroxy-α-amino lactones from α- furfuryl amide
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(S)- and (R)- α- furfuryl amides, obtained from the kinetic resolution of (R, S)- α- furfuryl amide using the modified Sharpless asymmetric epoxidation, have been transformed into four 8-hydroxy α- amino lactones (1S, 3S)-1, (1R, 3R)-1, (1S, 3R)-1, (1R, 3S)-1, using sharpless asymmetric dihydroxylation as the key step. The much more efficient method of the addition of chiral aldimine 10 with allylic Grignard reagent for preparation of (S, S)-1 was also achieved.
- Liao, Li-Xin,Zhou, Wei-Shan
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p. 12571 - 12584
(2007/10/03)
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- A new approach to clavalanine β-lactam antibiotic: Transformation of chiral α-furfuryl amide into the δ-hydroxyl-α-amino lactones via asymmetrical dihydroxylation
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Transformation of chiral α-furfuryl amide obtained from kinetic resolution into four δ-hydroxyl-α-amino lactones by utilizing the Sharpless ADH reaction as a key step was achieved.
- Liao, Li-Xin,Zhou, Wei-Shan
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p. 6371 - 6374
(2007/10/03)
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- Amino acids and peptides; 75. Synthesis of di- and trihydroxyamino acids - Construction of lipophilic tripalmitoyldihydroxy-α-amino acids
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Suitable protected derivatives of trihydroxynorleucines-[(2S,4S,5S)- and (2R,4S,5S)-2-amino-4,5,6-trihydroxyhexanoic acid], of all isomeric dihydroxynorvalines [2-amino-4,5-dihydroxypentanoic acids), of all isomeric 2-amino-6,7-dihydroxyheptanoic acids an
- Schmidt,Lieberknecht,Kazmaier,Griesser,Jung,Metzger
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