- Synthesis of desmosine-containing cyclic peptide for the possible elucidation of elastin crosslinking structure
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Elastin is a vital extracellular matrix protein, which is known for providing elasticity in numerous tissues. It is formed by the self-assembly and subsequent crosslinking of elastin precursor, tropoelastin. Two tetrafunctional, pyridinium-based amino acids desmosine and isodesmosine are exclusively found in elastin and play an important role as crosslinkers. Structural elucidation of elastin has eluded scientists to date, owing to the highly cross-linked structure and insoluble nature. Therefore, in this study, we aimed to synthesize a desmosine-containing cyclic peptide as a partial elastin mimic, in order to eventually facilitate the elucidation of the crosslinking pattern of elastin by mass spectrometric analysis.
- Ogawa, Keita,Hayashi, Takahiro,Lin, Yong Y.,Usuki, Toyonobu
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Read Online
- Nicotianamine-Derived Metallophore And Processes For Producing Same
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The invention relates to a nicotianamine derivative and to a process for chemical or enzymatic synthesis thereof. The nicotianamine derivative has the following formula (I). The invention finds use in the pharmacy field in particular.
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Page/Page column 3
(2012/04/23)
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- The crystallographic structure of thermoNicotianamine synthase with a synthetic reaction intermediate highlights the sequential processing mechanism
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We determined the three-dimensional structure of a complex between an archaeal nicotianamine synthase homologue and a chemically synthesised reaction intermediate. This structure suggests that the enzymes cavity allows both an ordered substrate binding an
- Dreyfus, Cyril,Larrouy, Manuel,Cavelier, Florine,Martinez, Jean,Pignol, David,Arnoux, Pascal
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supporting information; experimental part
p. 5825 - 5827
(2011/06/23)
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- Efficient synthesis of nicotianamine and non-natural analogues
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An efficient synthesis of nicotianamine has been achieved by using a new strategy based on N-alkylation. Sulfonamide activation proved to be necessary for the alkylation of the primary amine and the 2-(trimethylsilyl)ethanesulfonyl group was easily introd
- Bouazaoui, M'Barek,Larrouy, Manuel,Martinez, Jean,Cavelier, Florine
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experimental part
p. 6609 - 6617
(2011/02/25)
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- PYRIMIDINE DERIVATIVES USEFUL AS DHFR INHIBITORS
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Compounds of formula (I) or (II) are dihydrofolatereductase inhibitors, useful for the treatment of, for example, cell proliferative diseases: wherein A and D are independently -CHR6- or -NR6; E and G are independently =CR6/sub
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Page/Page column 24; 26
(2010/11/29)
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- Preparation of amino- and carboxy-protected L-α-amino-ω-iodocarboxylic acids
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The synthesis of L-α-amino-ω-iodobutyric, valeric, and caproic acid esters protected at the amino function by a benzyloxycarbonyl group is reported.
- Easmon,Heinisch,Holzer,Matuszczak
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p. 367 - 370
(2007/10/02)
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