- Method for synthesizing 3-(methylthio) dibenzenamine by light/nickel concerted catalysis
-
The invention discloses a method for synthesizing 3-(methylthio) dibenzenamine by light/nickel concerted catalysis. According to the method, cheap 3-(methylthio) benzenamine and halogeno benzene are used as raw materials, a light/nickel concerted catalysis strategy is used for constructing C-N bonds for the first time, and pyridazines drug key intermediate 3-(methylthio) dibenzenamine is synthesized. The method has the advantages that 1) the use amount of a photocatalyst is low, and is 0.01-0.02% of the molar weight of the halogeno benzene; 2) nickel salt is directly used as a metal catalyst such as nickel bromide, and an external ligand is not required; 3) reaction conditions are gentle, and can be effectively carried out at the temperature of 40-50 DEG C; and 4) the product can be directly obtained by reduced pressure distillation and is easily separated. By the remarkable advantages, the method has good industrial application prospect.
- -
-
Paragraph 0035; 0058-0059
(2018/09/11)
-