1333107-83-7Relevant articles and documents
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors
Gentile, Gabriella,Bernasconi, Giovanni,Pozzan, Alfonso,Merlo, Giancarlo,Marzorati, Paola,Bamborough, Paul,Bax, Benjamin,Bridges, Angela,Brough, Caroline,Carter, Paul,Cutler, Geoffrey,Neu, Margarete,Takada, Mia
, p. 4823 - 4827 (2011)
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3β inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.