Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents
A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.
A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides
A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.
Zekri, Negar,Alamdari, Reza Fareghi,Khalafi-Nezhad, Ali
experimental part
p. 299 - 304
(2012/04/23)
More Articles about upstream products of 1333311-80-0