Phenol compound ortho-position direct fluorination method
The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.
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Paragraph 0046-0048
(2020/04/17)
Selective Synthesis of Fluorophenol Derivatives
The selective synthesis of fluorophenol derivatives starting from tert-butylphenol derivatives and fluorinating reagents is described. tert-Butylfluorophenol derivatives were treated with an aluminum chloride catalyst in toluene to afford the fluorophenol derivatives.
Takemoto, Ichiki,Yamasaki, Kaori
p. 594 - 595
(2007/10/02)
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