Approach to preparative synthesis of ortho-(1-methylbut-2-en-1-yl)anilines, precursors of new cytotoxic heterocycles
The reaction of aromatic Claisen rearrangement of N-(1-methylbut-2-en-1-yl)anilines in the presence of p-toluenesulfonic acid was investigated. N-Tosyl-2-(1-iodoethyl)-3-methylindoline derivatives were obtained; one of them exhibited a cytotoxic activity.