133406-29-8

Basic information

• Product Name: ST034307
• Synonyms: ST034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one
• CAS NO: 133406-29-8
• Molecular Formula: C10H4Cl4O2
• Molecular Weight: 297.94956
• Mol File: 133406-29-8.mol

Chemical Properties

• Boiling Point: 329.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.674±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: ST034307(CAS DataBase Reference)
• NIST Chemistry Reference: ST034307(133406-29-8)
• EPA Substance Registry System: ST034307(133406-29-8)

Safety Data

• Hazardous Substances Data: 133406-29-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ST034307 is used as a selective adenylyl cyclase 1 (AC1) inhibitor for its potential role in modulating cellular signaling pathways and studying the effects of AC1 inhibition on various biological processes.
Used in Research Applications:
ST034307 is used as a research tool for exploring the involvement of AC1 in cellular signaling, which can help in understanding the mechanisms of various diseases and the development of targeted therapies.
Used in Pain Management:
ST034307 is used as an analgesic agent in a mouse model of inflammatory pain, indicating its potential use in the development of pain management therapies.
Used in Drug Development:
ST034307 is a useful intermediate in the development of drugs targeting adenylyl cyclase 1 (AC1) for the treatment of various diseases and conditions.

References

1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381 2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652 3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215

Upstream product

• 69693-00-1 6-chloro-2-methyl-4H-chromen-4-one 
• 288087-81-0 (Z)-3-Amino-4,4,4-trichloro-1-(5-chloro-2-hydroxy-phenyl)-but-2-en-1-one 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 

Downstream Products

• 19484-57-2 6-chloro-4-hydroxycoumarin 

Relevant articles and documents

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile as a route to 2-trichloromethylchromones and 4-hydroxycoumarins

Condensation of 2-hydroxyacetophenones with trichloroacetonitrile in the presence of N-methylanilinomagnesium bromide affords hydroxyaryl β-amino-β-trichloromethylvinyl ketones, which are converted into 2-trichloromethylchromones upon treatment with concentrated HCl. The resulting compounds react with alcoholic solutions of NH3 or KOH to form 3-amino-1-(2-hydroxyaryl)-4,4,4-trichlorobut-2-en-1-ones and 4-hydroxycoumarins, respectively.

SOME REACTIONS OF 6-CHLORO-2-METHYL-4H-1-BENZOPYRAN-4-ONE. I

4H-1-Benzopyran-4-ones (Chromones) are proved to be of special importance in medicine as stimulants of the central nervous system, spasmolytics, coronary dilators, inhibitors for the growth of human cancer cells, reductants for blood pressure, diuretics, antiallergic, antibiotics and cardiovascular agents. In the course of the present work several new derivatives containing the chromone moiety were prepared. Some of their reactions were investigated in the hope of obtaining new compounds having biological activities. The reactivities of chromone nucleus towards cycloaddition reactions under Diels-Alder conditions, nucleophilic and electrophilic reagents, photocyclodehydrogenation and thiation have been investigated.