- Spiro derivatives as lipoxygenase inhibitors
-
The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful
- -
-
Page/Page column 90
(2008/06/13)
-
- SUBSTITUTED ANILIDE LIGANDS FOR THE THYROID RECEPTOR
-
Novel thyroid receptor ligands are provided having the general formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12. and R13 are as defined herein. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolic dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.
- -
-
-
- Synthesis of a novel class of water-soluble and bioavailable antioxidants: 5-Hydroxycoumaran derivatives possessing imidazole group
-
The 5-hydroxycoumaran derivative 1 possessing imidazole group was synthesized from 2-isopropyl-6-methylphenol with high regioselectivity. The compound 1 was the water-soluble antioxidant with potent bioavailability and showed TXA2 synthase inhibition.
- Hasegawa, Tomoyuki,Yoshida, Koji,Hachiya, Katsutoshi,Miyazaki, Makoto,Tsuruta, Hiroshi,Nambu, Fumio,Ohuchida, Shuichi,Kawamura, Masanori
-
p. 511 - 512
(2007/10/03)
-