DNA-controlled bivalent presentation of ligands for the estrogen receptor
Molecular ruler: Steroid analogues were conjugated to DNA by using click chemistry, and self-assembly provided ternary DNA complexes with bivalent ligand presentation. The distance between the bound ligands was measured by spatial screening of the estrogen receptor, and a second hydrophobic binding site was postulated. The picture shows the DNA(black)-raloxifene(orange) complex in the ligand binding domain of the receptor. Copyright
Abendroth, Frank,Bujotzek, Alexander,Shan, Min,Haag, Rainer,Weber, Marcus,Seitz, Oliver
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