cas 13347-42-7, 2-CYCLOPENTYL-4-CHLOROPHENOL | Articles data ｜lookchem

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13347-42-7

Articles about 13347-42-7Total 2 be found

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2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
Sandham, David A.,Aldcroft, Clive,Baettig, Urs,Barker, Lucy,Beer, David,Bhalay, Gurdip,Brown, Zarin,Dubois, Gerald,Budd, David,Bidlake, Louise,Campbell, Emma,Cox, Brian,Everatt, Brian,Harrison, David,Leblanc, Catherine J.,Manini, Jodie,Profit, Rachael,Stringer, Rowan,Thompson, Katy S.,Turner, Katharine L.,Tweed, Morris F.,Walker, Christoph,Watson, Simon J.,Whitebread, Steven,Willis, Jennifer,Williams, Gareth,Wilson, Caroline
p. 4347 - 4350
(2008/12/20)

Regioselective alkylation of phenol with cyclopentanol over montmorillonite K10: An efficient synthesis of l-(2-cyclopentylphenoxy)-3-[(l,l-dimethylethyl)amino]propan-2-ol {(S')-penbutolol}
Regioselective alkylation of phenol with cyclopentanol is achieved over Montmorillonite K10 clay, producing 2-cycIopentylphenol, the key intermediate. The synthesis of optically active (S)-penbutoIol 1, an important antihypertensive drug, is realized in 5 steps from 2-cyclopentylphenol by employing Sharpless asymmetric dihydroxylation. The Royal Society of Chemistry 1999.
Phukan, Prodeep,Sudalai, Arumugam
p. 3015 - 3018
(2007/10/03)

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Chemical Properties

Boiling Point: 247.6°C at 760 mmHg
Flash Point:103.6°C
Density: 1.204g/cm³
Vapor Pressure: 0.0161mmHg at 25°C
Refractive Index: 1.5364 (estimate)
PKA: 9.93±0.43(Predicted)
PSA: 20.23000
LogP: 3.70320

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