- Microwave-assisted synthesis of alkyl thiocyanates
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Microwave irradiation accelerated the reaction of t-alkyl, allyl, and benzyl halides with Zn(SCN)2 to afford thiocyanates in excellent yields and high selectivity with the formation of isothiocyanates only in minor proportions. Because thiocyanates are stable intermediates to thiols, the method also affords facile access to corresponding thiols.
- Bound, D. James,Bettadaiah,Srinivas
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p. 1138 - 1144
(2013/03/28)
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- Ultrasound-assisted nucleophilic substitution reaction of t-Alkyl halides with zinc and titanium thiocyanate
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Ultrasound promotes nucleophilic substitution of t-alkyl halides with ambident thiocyanate nucleophile, in the form of its zinc or titanium thiocyanate, under mild conditions to afford the corresponding thiocyanates selectively, in good to excellent yields. This improved synthetic methodology affords a facile access to tertiary thiols via the corresponding thiocyanate intermediates.
- Bettadaiah,Gurudutt,Srinivas
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p. 2293 - 2299
(2007/10/03)
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- Simple synthetic protocols for tertiary alkyl and allyl thiols
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Convenient preparative methods for tertiary alkyl and allyl thiols are described. Accordingly, thiolesters and thiocyanates, obtained from the reaction of SN1-active halides and appropriate zinc salts, on hydrolysis and LAH reduction respectively, afford the corresponding thiols in near quantitative yields. Besides the well known p-menth-1-ene-8-thiol, p-menthane-1-thiol, p-mentha-1,8-diene-6-thiol and 2-(2-phenyl)propane thiol have been prepared.
- Gurudutt, K. N.,Rao, Sanjay,Srinivas, P.,Srinivas, S.
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p. 1169 - 1171
(2007/10/03)
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