Nickel-Catalyzed Directed Cross-Electrophile Coupling of Phenolic Esters with Alkyl Bromides
Herein, we demonstrate the successful use of robust phenolic esters as an electrophilic acyl source in the reaction with diverse primary and secondary unactivated alkyl bromides. The cleavage of the relatively inert C-O bond is facilitated by the neighboring coordinating hydroxyl or sulfonamide moiety. By circumventing the use of pregenerated organometallics, this method allows efficient preparation of a variety of o-hydroxyl and tosyl-protected o-amino aryl ketones with high compatibility with a wide range of functionalities.
Ding, Decai,Wang, chuan,Yang, feiyan
supporting information
p. 9203 - 9209
(2020/12/22)
Some fatty acids having an O-heterocycle in their terminal positions. I.ω-(3-chromonyl)alkanoic acids
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Yamaguchi,Mutoh,Shimakura,Tsuzuki,Kawase
p. 119 - 123
(2007/10/02)
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