133562-39-7

Basic information

• Product Name: 2-amino-1-(4-ethylphenyl)ethanol
• Synonyms: 2-amino-1-(4-ethylphenyl)ethanol;AKOS BBV-003148;OTAVA-BB 1055865;2-Amino-1-(4-ethylphenyl)ethan-1-ol
• CAS NO: 133562-39-7
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.234
• Mol File: 133562-39-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-1-(4-ethylphenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1-(4-ethylphenyl)ethanol(133562-39-7)
• EPA Substance Registry System: 2-amino-1-(4-ethylphenyl)ethanol(133562-39-7)

Safety Data

• Hazardous Substances Data: 133562-39-7(Hazardous Substances Data)

Usage

Also Known As

4-Ethylphenylethanolamine

Molecular Weight

165.23 g/mol

Functional Groups

Amine group (-NH2)
Hydroxyl group (-OH)
Ethylphenyl group (C6H5-CH2-CH2-)

Potential Applications

Pharmaceuticals
Medicinal chemistry

Properties

Derivative of phenethylamine
Building block for synthesis of biologically active compounds

Further Studies

Precise uses and properties subject to additional research and studies.

Upstream product

• 4748-78-1 4-ethylbenzylaldehyde 

Downstream Products

• 1407597-27-6 C₂₄H₄₁NO₂ 

Relevant articles and documents

Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases

In the present study we describe the design and synthesis of a series of amide- and sulfonamide-based compounds as inhibitor of recombinant acid and neutral ceramidases. Inhibition of ceramidases has been shown to induce apoptosis and to increase the efficacy of conventional chemotherapy in several cancer models. B-13, lead in vitro inhibitor of acid ceramidase has been recently shown to be virtually inactive towards lysosomal acid ceramidase in living cells at lower concentrations and for a shorter time of treatment, suggesting the development of more potent inhibitors. In this study, a detailed SAR investigation has been performed to understand the effect of different substituents on the phenyl ring of amide- and sulfonamide-based compounds that partially resemble the structure of well-known inhibitors such as B-13, D-e-MAPP as well as NOE. Our results suggest that the electronic effects of the substituents on phenyl ring in B-13 and D-e-MAPP analogues have negligible effects either in enhancing the inhibition potencies or for selectivity towards aCDase over nCDase. However, the hydrophobicity and the steric effects of longer alkyl chains (n-Pr, n-Bu or t-Bu groups) at the phenyl ring were found to be important for an enhanced selectivity towards aCDase over nCDase.