- SYNTHESIS OF STEROIDAL OXATHIOLANE THIONES
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The reaction of 5,6α-oxido-5α-cholestane (1) with carbon disulfide in the presence of triethylamine at room temperature affords 5α-cholestano-1',3'-oxathiolane-2'-thione (5).Under similar reaction conditions, its 3β-hydroxy (2), 3β-acetoxy (3) and 3β-chloro (4) analogues give 3β-hydroxy-5α-cholestano-1',3'-oxathiolane-2'-thione (6), 3β-acetoxy-5α-cholestano-1',3'-oxathiolane-2'-thione (7), and 3β-chloro-5α-cholestano-1',3'-oxathiolane-2'-thione (8), respectively.The structures of these compounds have been established on t he basis of elemental analyses and the spectral values.
- Shafiullah,Shamsuzzaman,Pathak, Rajesh Kumar
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p. 701 - 704
(2007/10/02)
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