- The electronic effects of ligands on metal-coordination geometry: A key role in the visual discrimination of dimethylaminopyridine and its application towards chemo-switch
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Due to its special coordination ability to Cu(ii)-terpyridine complexes, a simple and straightforward visual recognition of p-DMAP out of its analogues has been realized via selective metallogel collapse. In combination with the selective gel collapse and the self-healing properties of metallohydrogel 1a, its potential application towards chemo-switch is also demonstrated.
- Fang, Weiwei,Liu, Cong,Chen, Jiangbo,Lu, Zhengwei,Li, Zhi-Ming,Bao, Xiaoling,Tu, Tao
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- Copper chloride complexes with substituted 4′-phenyl-terpyridine ligands: synthesis, characterization, antiproliferative activities and DNA interactions
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Eleven copper chloride coordination compounds (1-11) with 4′-(4′-substituted-phenyl)-2,2′:6′,2′′-terpyridine ligands bearing hydrogen (L1), cyano (L2),p-hydroxyl (L3),m-hydroxyl (L4),o-hydroxyl (L5), methoxyl (L6), iodo (L7), bromo (L8), chloro (L9), fluoro (L10) or methylsulfonyl (L11) were prepared and characterized by IR spectroscopy, elemental analysis and single crystal X-ray diffraction. Antiproliferative activities against tumor cells were investigated and DNA interactions were studied by circular dichroism spectroscopy and molecular modeling methods.In vitrodata demonstrate that all the compounds exhibit higher antiproliferative activities as compared to cisplatin against five human carcinoma cell lines: A549, Bel-7402, Eca-109, HeLa and MCF-7. Compound6with methoxyl shows the best anti-proliferation activity. Spectrophotometric results reveal the strong affinity of the compounds for binding with DNA as intercalators and induce DNA conformational transitions. The results of molecular docking studies show that the compounds interact with DNA through π-π stacking, van der Waals forces, hydrophobic interactions and hydrogen bonds. The binding energies between compound11and three macromolecules, including DNA duplex, oligonucleotide and DNA-Topo I complex, are the lowest. The binding stability of compounds containing hydroxyl, methoxy and methylsulfonyl groups with biological macromolecules mainly relies on the hydrogen bonds. The ability of a compound to form hydrogen bonds can promote its binding to biological targets, thereby exhibiting high antiproliferative activity.
- Chen, Hailan,Li, Jiahe,Liu, Rongping,Luo, Baomei,Ma, Zhen,Pan, Lixia,Wang, Zhiyuan,Yan, Hao,Yang, Dengfeng
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