Synthesis and antiestrogenic activity of the compounds related to the metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1- butenyl]phenyl monophosphate (TAT-59)
The metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy)phenyl]-2-(4-isopropylphenyl)-1- butenyl]phenyl monophosphate, TAT-59, (1), a potent antitumor agent for hormone-dependent tumors, and derivatives of TAT-59 were synthesized to confirm its proposed s