Synthesis method of montelukast sodium intermediate
The invention provides a synthesis method of a montelukast sodium intermediate. The synthesis method comprises the following steps: (1) carrying out Witting reaction on a compound (IV) and 3-bromobenzyl bromide to obtain a compound (II); and (2) carrying out a coupling reaction on the compound (II) and a compound (III) under the action of a palladium catalyst to obtain the compound (I). The synthesis method is short in step, mild in condition, easyand convenient to operate, beneficial to reducing the process cost and capable of realizing industrial production.
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Paragraph 0012; 0040-0045
(2020/11/10)
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