Total synthesis and stereochemical revision of acortatarins A and B
A first total synthesis of acortatarins A, B, and an enantiomer of the proposed structure of acortatarin B is described by using readily available d-sugars. This convergent total synthesis revealed the revision of the absolute configuration of acortatarin A and structural revision of acortatarin B. The key steps involved are regioselective epoxide opening with deprotonated 2,5-disubstituted pyrrole and spiroketalization.
Sudhakar, Gangarajula,Kadam, Vilas D.,Bayya, Shruthi,Pranitha, Gavinolla,Jagadeesh, Bharatam
p. 5452 - 5455
(2011/12/05)
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