- Synthesis, anti-inflammatory, analgesic, and antibacterial activities of some triazole, triazolothiadiazole, and triazolothiadiazine derivatives
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This study is concerned with the synthesis of new 1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4- thiadiazines derivatives. Derivatives 3a-i were obtained by condensation of 4-amino-3-(4-pyridine)- 5-mercapto-1,2,4-triazole 1 with the appropriate aldehyde
- Hussein, Mostafa A.,Shaker, Refaat M.,Ameen, Mohammed A.,Mohammed, Mohammed F.
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experimental part
p. 1239 - 1250
(2012/05/20)
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- Synthesis of some 5-substituted-1,2,4-triazole-3-thiones, containing thiourea, arylidenamino and morpholin-4-yl methyl fragments
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In this study, first 4-amino-5-(pyridine-4yl)-4H-1,2,4-triazole-3- thione (1) and 4-amino-5-(2-hydroxyphenyl)-4H-1,2,4-triazole-3-thione (2) were synthesized. In the second step (1) and (2) compounds undergo reaction with aryl isothiocyanates in dry C6H6 to give corresponding N-substituted thiourea derivatives (3a-d and 4a-d). In addition, in the another reaction (1) and (2) compounds were reacted with some aromatic aldehyde in anhydrous ethanol to give corresponding arylidenamino compounds (5a-d and 6a-d). In the third step, aminomethylation derivatives (7a-d and 8a-d) were obtained by the Mannich reactions of arylidenamino compounds (5a-d and 6a-d), with formaldehyde/ morpholine in ethanol. The structures of all the synthesized compounds were confirmed by elemental analyses, FT-IR, 1H and 13C NMR spectra.
- Koparir, Metin,Koparir, Pelin,Cansiz, Ahmet,Temuz, Mehmet Mursit
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experimental part
p. 6059 - 6066
(2010/12/24)
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- Efficient and convenient protocol for the synthesis of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
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The novel triazolothiadiazine analogs 5a-p were obtained via a multistep synthetic sequence beginning with 5-substituted 4-amino-1,2,4-triazole-3-thiols 1. Compound 1, in reaction with various aromatic aldehydes 2 in acetic acid, afforded Schiff bases 3a-
- Foroughifar, Naser,Mobinikhaledi, Akbar,Ebrahimi, Sattar
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experimental part
p. 2421 - 2428
(2010/09/05)
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