- Compound
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PROBLEM TO BE SOLVED: To provide a compound capable of forming a color filter excellent in heat resistance. SOLUTION: The present invention provides a compound represented by formula (I). [In formula (I), R1-R8 independently represen
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Paragraph 0180-0182
(2020/05/02)
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- Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists
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Novel series of compounds consisting of 2-amidocyclohex-1-ene carboxylate and phenyl parts which are connected by enyne (compounds 2a–f), but-1-yne (compounds 4a–j), and phenylethylene (compounds 5a–f) linkers as HCA2 full agonists were designed and their
- Bobileva, Olga,Ikaunieks, Martins,Duburs, Gunars,Mandrika, Ilona,Petrovska, Ramona,Klovins, Janis,Loza, Einars
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p. 4314 - 4329
(2017/07/22)
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- COMPOSITIONS OF NOVEL OPIOID COMPOUNDS AND METHOD OF USE THEREOF
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Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.
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Page/Page column 17
(2010/11/24)
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- ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS
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Hydroxamic acids having formula (B) wherein the variables are as defined herein, are useful in treating disease conditions mediated by TNF- alpha such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's d
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- 2,5-DISUBSTITUTED 3-MERCAPTOPENTANOIC ACID
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The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases wher
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- The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation
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(Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Δ3,4-chromenes the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring.
- Pelter, Andrew,Hussain, Amjad,Smith, Gareth,Ward, Robert S.
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p. 3879 - 3916
(2007/10/03)
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- Arocalciferols: Synthesis and biological evaluation of aromatic side-chain analogues of 1α,25-dihydroxyvitamin D31a
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Aromatic side-chain analogues (arocalciferols 6-9) of the steroid hormone 1α,25-dihydroxyvitamin D3 (1) were synthesized and biologically evaluated. The analogues were prepared by coupling the vitamin D A-ring enyne 14 with the appropriate enol
- Figadere,Norman,Henry,Koeffler,Zhou,Okamura
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p. 2452 - 2463
(2007/10/02)
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