Folate analogues. 35. synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of n10-propargyl-5, 8-dideazafolic acid1
Structural modifications at the pyrimidine ring and at the C9,N10-bridge region of the thymidylate synthase (TS) inhibitors N10-propargyl-5,8-dideazafolate (1; PDDF; CB 3717), 2-desamino-N10-propargyl-5,8-dideaz