1339892-52-2

Basic information

• Product Name: 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• Synonyms: 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(2-methanesulfonylethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;(1-(2-(METHYLSULFONYL)ETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1339892-52-2
• Molecular Formula: C₁₂H₂₁BN₂O₄S
• Molecular Weight: 300.18214
• Mol File: 1339892-52-2.mol

Chemical Properties

• Boiling Point: 487.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.62±0.10(Predicted)
• CAS DataBase Reference: 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(1339892-52-2)
• EPA Substance Registry System: 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(1339892-52-2)

Safety Data

• Hazardous Substances Data: 1339892-52-2(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is used as a reagent in medicinal chemistry for its ability to participate in organic transformations. The boron atom in the compound facilitates reactions that can lead to the synthesis of new pharmaceutical compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a versatile building block. Its structural components, including the pyrazole ring and the boron-containing group, allow for the creation of diverse organic molecules through various synthetic routes, expanding the scope of chemical libraries for drug discovery and development.
Used in Drug Development:
The presence of the methylsulfonyl group in 1-(2-(Methylsulfonyl)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole may impart specific pharmacological properties to the molecule, making it a candidate for drug development. Further experimental research is required to explore its potential as a therapeutic agent, including its interactions with biological targets and its efficacy and safety profiles.

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 3680-02-2 methyl ethenyl sulphone 

Relevant articles and documents

HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF

The present invention provides herein is a heteroaryl compound or a stereoisomer, a geometric isomer, a tautomer, a racemate, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, as well as a pharmaceutical composition containing the compound disclosed herein. The present invention also provides herein is use of the compound or the pharmaceutical composition thereof disclosed herein in the manufacture of a medicine for treating autoimmune diseases or proliferative diseases.

5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES

Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.