134111-35-6Relevant articles and documents
MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF
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Page/Page column 49, (2021/10/11)
The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard 4' -thio nucleoside.
The synthesis and biological activity of certain 4'-thionucleosides
Secrist III,Parker,Tiwari,Messini,Shaddix,Rose,Bennett Jr.,Montgomery
, p. 675 - 686 (2007/10/02)
Results are presented on the synthesis and biological activity of several types of 4'-thionucleosides as potential anticancer agents. Detailed studies on the mechanism of action of 4'-thiothymidine are also presented.
Synthesis and Biological Activity of 2'-Deoxy-4'-thio Pyrimidine Nucleosides
Secrist, John A.,Tiwari, Kamal N.,Riordan, James M.,Montgomery, John A.
, p. 2361 - 2366 (2007/10/02)
2'-Deoxy-4'-thiocytidine (7β), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro.All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also act
The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues
Dyson,Coe,Walker
, p. 2782 - 2786 (2007/10/02)
Starting from benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside (4), the following 2'-deoxy nucleoside analogues have been synthesized: 4'-thiothymidine (8), 3'-azido-4'-thio-deoxythymidine (10), and (E)-5-(2-bromovinyl)-4'-thio-2'-deoxy