134141-09-6Relevant articles and documents
Larvicidal study of tetrahydropyrimidine scaffolds against Anopheles arabiensis and structural insight by single crystal X-ray studies
Bairagi, Keshab M.,Venugopala, Katharigatta N.,Mondal, Pradip Kumar,Gleiser, Raquel M.,Chopra, Deepak,García, Daniel,Odhav, Bharti,Nayak, Susanta K.
, p. 1924 - 1932 (2018)
A series of methyl or ethyl 4-(substitutedphenyl/pyridyl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (HPM) analogues 4a–g were synthesized and evaluated for larvicidal activity against Anopheles arabiensis. These newly synthesized co
Antidiabetic activity of dihydropyrimidine scaffolds and structural insight by single crystal x-ray studies
Alwassil, Osama I.,Bairagi, Keshab M.,Emeka, Promise Madu,Gonnade, Rajesh G.,Khalil, Hany Ezzat,Nayak, Susanta K.,Sangtani, Ekta,Venugopala, Katharigatta N.,Younis, Nancy Safwat
, p. 996 - 1003 (2020/08/19)
Background: This research project is designed to identify the anti-diabetic effects of the newly synthesized compounds to conclude the perspective of consuming one or more of these new synthetic compounds for diabetes management. Introduction: A series of
A reactant promoted solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-thione analogues using ammonium thiocyanate
Khatri, Chetan K.,Potadar, Santoshkumar M.,Chaturbhuj, Ganesh U.
supporting information, p. 1778 - 1780 (2017/04/13)
This is the first-time ammonium thiocyanate (NH4SCN) has been used as a self-promoting reactant for the synthesis of 3,4-dihydropyrimidin-2(1H)-thiones. This report describes a greener, efficient and economic protocol for one pot three-component synthesis of Biginelli compounds using various aldehydes, β-ketoesters and ammonium thiocyanate. Ammonium thiocyanate being a weak acid, accelerate the rate of reaction to obtain Biginelli compounds in solvent-free condition at 110?°C. The key advantages of the present method are high yields, short reaction time, solvent free condition, easy workup and ability to tolerate a variety of functional groups. Ammonium thiocyanate is readily available, cheaper, safer and industrial acceptable material which gives economical as well as ecological rewards to the present method.