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134162-37-1

8-(Benzenesulfonamido)-7-(3-pyridinyl)octanoic acid is a synthetic arylsulfonamido alkanoic acid derivative designed to exhibit dual thromboxane synthase inhibition (TxSI) and thromboxane receptor antagonism (TxRA) activities. It demonstrates efficacy in inhibiting thromboxane A2 (TxA2) biosynthesis and platelet aggregation in vitro, making it a candidate for therapeutic applications in circulatory and renal disorders. However, structural modifications may influence its pharmacological profile, as certain derivatives have shown unintended agonist effects on thromboxane receptors.

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  • 134162-37-1 Structure

  • Basic information

    1. Product Name: 8-Bspoa
    2. Synonyms: 8-(benzenesulfonamido)-7-(3-pyridinyl)octanoic acid
    3. CAS NO:134162-37-1
    4. Molecular Formula: C19H24 N2 O4 S
    5. Molecular Weight: 376.47
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 134162-37-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 598.3°Cat760mmHg
    3. Flash Point: 315.6°C
    4. Appearance: /
    5. Density: 1.234g/cm3
    6. Vapor Pressure: 3.67E-15mmHg at 25°C
    7. Refractive Index: 1.572
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 8-Bspoa(CAS DataBase Reference)
    11. NIST Chemistry Reference: 8-Bspoa(134162-37-1)
    12. EPA Substance Registry System: 8-Bspoa(134162-37-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134162-37-1(Hazardous Substances Data)

134162-37-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 134162-37-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,1,6 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 134162-37:
(8*1)+(7*3)+(6*4)+(5*1)+(4*6)+(3*2)+(2*3)+(1*7)=101
101 % 10 = 1
So 134162-37-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H24N2O4S/c22-19(23)12-6-1-3-8-17(16-9-7-13-20-14-16)15-21-26(24,25)18-10-4-2-5-11-18/h2,4-5,7,9-11,13-14,17,21H,1,3,6,8,12,15H2,(H,22,23)

134162-37-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-(benzenesulfonamido)-7-pyridin-3-yloctanoic acid

1.2 Other means of identification

Product number -
Other names 8-(Benzenesulfonamido)-7-(3-pyridinyl)octanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134162-37-1 SDS

134162-37-1Downstream Products

134162-37-1Relevant articles and documents

CERTAIN (ARYLSULFONAMIDO- AND IMIDAZOLYL-)-SUBSTITUTED CARBOXYLIC ACIDS AND DERIVATIVES THEREOF AND USE FOR SUPPRESSING THROMBOXANE ACTIVITY

-

, (2008/06/13)

The present invention is concerned with compounds of formula I STR1 wherein A, B, M, R, Ar and Het are as defined in the specification, pharmaceutically acceptable ester and amide derivatives thereof; N-oxides thereof, tetrazole derivatives thereof, and s

Thromboxane Receptor Antagonism Combined with Thromboxane Synthase Inhibition. 2. Synthesis and Biological Activity of 8-(Benzenesulfonamido)-7-(3-pyridinyl)octanoic Acid and Related Compounds

Main, Alan J.,Goldstein, Robert,Cohen, David S.,Furness, Patricia,Lee, Warren

, p. 4362 - 4365 (2007/10/02)

A series of arylsulfonamido alkanoic acids substituted with a 3-pyridinyl group along the aliphatic chain were synthesized and tested in vitro for their ability to antagonize thromboxane A2 (TxA2) receptors and inhibit thromboxane sy

(Arylsulfonamido- and pyridyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity

-

, (2008/06/13)

Disclosed are the compounds of formula STR1 wherein A represents lower alkylene; B represents oxygen, sulfur, lower alkylene, lower alkylene interrupted by oxygen, sulfur, sulfinyl or sulfonyl, (oxy-, sulfinyl-, sulfonyl- or thio)-lower alkylene, lower al

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