Medium-Ring γ-Epoxy Sulfones. Regio- and Stereochemistry of the Butyllithium-Promoted Transannular Epoxide Ring Opening
Cyclic 8- and 9-membered E and Z γ-epoxy sulfones yield bicyclic hydroxy sulfones stereospecifically upon treatment with BuLi in THF.The distribution of regioisomeric products markedly depends on the metalation mode, portionwise or at once.This suggests t