1343839-05-3Relevant articles and documents
Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors
Yang, Xintuo,Pang, Xuehai,Fan, Lei,Li, Xinghai,Chen, Yuanwei
, p. 1919 - 1922 (2017/04/10)
This letter presents synthesis and structure-activity relationship study of sulfonamide derivatives as inhibitors of Human Uric Acid Transporter 1 (hURAT1). Among all tested sulfonamide derivatives, compounds 9b, 16i and 19b exhibited excellent inhibition activity with IC50 value of 10, 2, and 83?nM, respectively. In addition, compounds 9b and 19b demonstrated moderate PK profile in rats.
Benzenylsulfonylamide compound, preparation method thereof, application of benzenylsulfonylamide compound used as human urate transporter inhibitor medicine
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Paragraph 0250-0252, (2017/08/02)
The invention discloses a benzenylsulfonylamide compound as shown in a formula (A), a preparation method thereof, and application of the benzenylsulfonylamide compound used as a human urate transporter inhibitor medicine. Various compounds, and salt, an aquo-complex or a solvate thereof provided by the invention are selective uric acid reuptake inhibitors, so that hyperuricemia and gout can be treated through promoting uric acid to excrete from a human body and reducing serum uric acid.