13441-51-5

Basic information

• Product Name: D-KYNURENINE
• Synonyms: D-2-AMINO-4-[2-AMINOPHENYL]-4-OXOBUTANOIC ACID;D-KYNURENINE;D-kynurenine free base;β-Anthraniloyl-D-alanine;(2R)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;β-Anthraniloyl-D-alanine, D-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid;(R)-α,2-Diamino-γ-oxobenzenebutanoic acid;R-2-Amino-4-[2-aminophenyl]-4-oxobutanoic acid
• CAS NO: 13441-51-5
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.21
• Product Categories: API intermediates;Amino Acids
• Mol File: 13441-51-5.mol

Chemical Properties

• Boiling Point: 466.556 °C at 760 mmHg
• Flash Point: 235.965 °C
• Appearance: /
• Density: 1.344 g/cm³
• Vapor Pressure: 1.66E-09mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• PKA: 2.21±0.23(Predicted)
• CAS DataBase Reference: D-KYNURENINE(CAS DataBase Reference)
• NIST Chemistry Reference: D-KYNURENINE(13441-51-5)
• EPA Substance Registry System: D-KYNURENINE(13441-51-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13441-51-5(Hazardous Substances Data)

Usage

Biochem/physiol Actions

D-Kynurenine may be used along with L-kynurenine to assess the specificity and kinetics of kynurenine metabolizing enzymes. D-Kynurenine is used to study the selectivity and activity of the G protein-coupled receptor, GPR109B. D-Kynurenine is used as a substrate in a fluorometric assay of D-amino acid oxidase.

InChI:InChI=1/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m1/s1

Upstream product

• 343-65-7 Kynurenine 
• 32999-55-6 oxindolylalanine 
• 73-22-3 L-tryptophan 
• 32999-55-6 2-Amino-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-propionic acid 

Downstream Products

• 363-36-0 kynuramine 

Relevant articles and documents

Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase

A modified macrocyclic glycopeptide-based chiral stationary phase (CSP), prepared via Edman degradation of vancomycin, was evaluated as a chiral selector for the first time. Its applicability was compared with other macrocyclic glycopeptide-based CSPs: TeicoShell and VancoShell. In addition, another modified macrocyclic glycopeptide-based CSP, NicoShell, was further examined. Initial evaluation was focused on the complementary behavior with these glycopeptides. A screening procedure was used based on previous work for the enantiomeric separation of 50 chiral compounds including amino acids, pesticides, stimulants, and a variety of pharmaceuticals. Fast and efficient chiral separations resulted by using superficially porous (core-shell) particle supports. Overall, the vancomycin Edman degradation product (EDP) resembled TeicoShell with high enantioselectivity for acidic compounds in the polar ionic mode. The simultaneous enantiomeric separation of 5 racemic profens using liquid chromatography-mass spectrometry with EDP was performed in approximately 3?minutes. Other highlights include simultaneous liquid chromatography separations of rac-amphetamine and rac-methamphetamine with VancoShell, rac-pseudoephedrine and rac-ephedrine with NicoShell, and rac-dichlorprop and rac-haloxyfop with TeicoShell.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.