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CAS

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134418-28-3

Dehydroandrographolide is a natural diterpenoid compound derived from Andrographis paniculata, a plant commonly known as "king of bitters." It exhibits a wide range of pharmacological properties, including anti-inflammatory, antiviral, and hepatoprotective effects. Its unique structure and bioactivity make it a promising candidate for various therapeutic applications.

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  • 134418-28-3 Structure

  • Basic information

    1. Product Name: Dehydroandrographolide
    2. Synonyms: ANDROGRAPHOLIDE, DEHYDRO-;DEHYDROANDROGRAPHOLIDE;14-Deoxy-11-dehydroandrographolide;Dehydroandrographoline;14-(P);DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Dehydroanddrographolide;(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone
    3. CAS NO:134418-28-3
    4. Molecular Formula: C20H28O5
    5. Molecular Weight: 348.43
    6. EINECS: N/A
    7. Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
    8. Mol File: 134418-28-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 519.621oC at 760 mmHg
    3. Flash Point: 182.403oC
    4. Appearance: /
    5. Density: 1.174g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.567
    8. Storage Temp.: N/A
    9. Solubility: Acetic Acid (Very Slightly), DMSO (Slightly), Ethanol (Very Slightly)
    10. PKA: 14.84±0.70(Predicted)
    11. CAS DataBase Reference: Dehydroandrographolide(CAS DataBase Reference)
    12. NIST Chemistry Reference: Dehydroandrographolide(134418-28-3)
    13. EPA Substance Registry System: Dehydroandrographolide(134418-28-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 24/25
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134418-28-3(Hazardous Substances Data)

134418-28-3 Usage

Uses

Used in Pharmaceutical Industry:
Dehydroandrographolide is used as an antiviral agent for its activity against hepatitis B virus (HBV) DNA replication. It inhibits the replication of the virus, providing a potential treatment option for individuals suffering from HBV infection.
Used in Hepatoprotective Applications:
Dehydroandrographolide serves as a hepatoprotective agent, protecting the liver from damage caused by various factors such as toxins, chemicals, and viral infections. Its hepatoprotective properties make it a valuable component in the development of drugs and supplements aimed at maintaining liver health and function.

Check Digit Verification of cas no

The CAS Registry Mumber 134418-28-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,1 and 8 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 134418-28:
(8*1)+(7*3)+(6*4)+(5*4)+(4*1)+(3*8)+(2*2)+(1*8)=113
113 % 10 = 3
So 134418-28-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16?,17-,19+,20+/m1/s1

134418-28-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Dehydroandrographolide

1.2 Other means of identification

Product number -
Other names Dehydrographkide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134418-28-3 SDS

134418-28-3Upstream product

134418-28-3Downstream Products

134418-28-3Related news

Microbial transformation of Dehydroandrographolide (cas 134418-28-3) by Cunninghamella echinulata07/31/2019

The capabilities of 24 strains of filamentous fungi (from 11 genera) to transform dehydroandrographolide (1) were screened. The highly region-specific hydroxylation of 1 at C-9 by Cunninghamella echinulata AS 3.3400 was observed. Five products were obtained, and they were identified as 9β-hydro...detailed

Dehydroandrographolide (cas 134418-28-3) inhibits IgE-mediated anaphylactic reactions via calcium signaling pathway07/30/2019

The classical mast cells degranulation pathway is mediated by FcεRI aggregation and varies in strength among subjects. Dehydroandrographolide (DA) is one of principal components of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) and considered the main contributors of its therapeut...detailed

Design, synthesis, and biological evaluation of novel nitric oxide releasing Dehydroandrographolide (cas 134418-28-3) derivatives07/29/2019

A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K56...detailed

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