- Formation of Imidazolones by Ring Closure of α-Isocyanoamides: Exploring New Reactivities
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Base-mediated ring closure of α,α-disubstituted α-isocyanoamides with further electrophilic trapping has previously been explored, but with limited applications. In this work, we wished to unravel the reactivities of these compounds and, in particular, to allow palladium-catalyzed coupling at the C2 position.
- Baudequin, Christine,Bischoff, Laurent,Frippiat, Steven,Hoarau, Christophe,Leterrier, Claire
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p. 1211 - 1215
(2020/07/20)
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- Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides
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The reaction between arynes and secondary α,α′-disubstituted α-isocyanoacetamides was developed to access 2-arylimidazolones of structural diversity and complexity in a straightforward manner.
- Gesù, Alessandro,Pozzoli, Claudio,Torre, Enza,Aprile, Silvio,Pirali, Tracey
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supporting information
p. 1992 - 1995
(2016/06/01)
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- Pd-Catalyzed direct C-H functionalization of imidazolones with aryl- and alkenyl halides
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Direct C-H arylation and alkenylation of 4,4′-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors. This journal is
- Muselli, Mickal,Baudequin, Christine,Hoarau, Christophe,Bischoff, Laurent
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supporting information
p. 745 - 748
(2015/01/09)
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- Studies on Isocyanides and Related Compounds. - Synthesis and Cyclization of N-Substituted 1-Isocyano-1-cycloalkanecarboxamides
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The Ugi four-component condensation between cycloalkanones, isocyanides, and ammonium formate affords N-substituted 1-formylamino-1-cycloalkanecarboxamides 1 which are dehydrated to give the corresponding isocyanides 2.Compounds 2 are cyclized with arylsu
- Bossio, Ricardo,Marcaccini, Stefano,Paoli, Paola,Papaleo, Sandro,,Pepino, Roberto,Polo, Cecilia
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p. 843 - 849
(2007/10/02)
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