Studies on Isocyanides and Related Compounds. - Synthesis and Cyclization of N-Substituted 1-Isocyano-1-cycloalkanecarboxamides
The Ugi four-component condensation between cycloalkanones, isocyanides, and ammonium formate affords N-substituted 1-formylamino-1-cycloalkanecarboxamides 1 which are dehydrated to give the corresponding isocyanides 2.Compounds 2 are cyclized with arylsu