Supported 3,5-disubstituted chiral hydantoin: A practical catalyst for the asymmetric hydrocyanation of 3-phenoxybenzaldehyde
A novel synthesis of six (R)-3,5-disubstituted chiral hydantoins in mixed solvent is reported. The catalysts were supported on a new polymeric resin afterwards and their enantioselectivities are examined via the asymmetric hydrocyanation of 3-phenoxybenzaldehyde.
Asymmetric Hydrocyanation of Benzaldehydes Catalysed by (5R)-5-(4-Imidazolylmethyl)-2,4-imidazolidinedione
The catalytic activity of (5R)-5-(4-imidazolylmethyl)-2,4-imidazolidinedione (3) was examined in the asymmetric hydrocyanation of 3-phenoxybenzaldehyde (1a) to (S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile ((S)-2a), an important alcohol moiety of optically active pyrethroid insecticides.Among the catalysts, 3-benzyl derivative (3d) exhibited moderate enantioselectivities for 1a and other benzaldehydes.
Danda, Hidenori
p. 3743 - 3745
(2007/10/02)
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