A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest.
Morley, Andrew D.,Cook, Andrew,King, Sarah,Roberts, Bryan,Lever, Sarah,Weaver, Richard,MacDonald, Cathy,Unitt, John,Fagura, Malbinder,Phillips, Tim,Lewis, Richard,Wenlock, Mark
p. 6456 - 6460
(2011/11/29)
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