134651-05-1Relevant articles and documents
Transformations in the isoxazole series: Synthesis of substituted 2-aminothiazoles
Pascual, Alfons
, p. 531 - 542 (2007/10/02)
Substitued N-(isoxazol-4-yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one-pot reaction. In a few cases, 1,4,5-trisubstituted dihydroimidazoleth, iones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed.