Preclinical Characterization of the FAAH Inhibitor JNJ-42165279
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channel
Keith, John M.,Jones, William M.,Tichenor, Mark,Liu, Jing,Seierstad, Mark,Palmer, James A.,Webb, Michael,Karbarz, Mark,Scott, Brian P.,Wilson, Sandy J.,Luo, Lin,Wennerholm, Michelle L.,Chang, Leon,Rizzolio, Michele,Rynberg, Raymond,Chaplan, Sandra R.,Breitenbucher, J. Guy
supporting information
p. 1204 - 1208
(2015/12/23)
MODULATORS OF FATTY ACID AMIDE HYDROLASE
4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1 -carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1 -carboxylic acid (4-chloro-pyridin-3-yl)-
-
Page/Page column 24-26
(2011/11/30)
More Articles about upstream products of 1346528-50-4