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1346607-05-3

GSK621 is a small molecule chemical compound that functions as a selective inhibitor of the enzyme AMP-activated protein kinase (AMPK), which is essential for maintaining cellular energy homeostasis. By inhibiting AMPK activity in various cell types, GSK621 suppresses cellular energy production and induces cell death. GSK621 has been studied for its potential therapeutic applications in diseases such as cancer and metabolic disorders due to its ability to disrupt cellular energy metabolism. Furthermore, GSK621 has been investigated for its potential in modulating inflammation and immune responses, making it a promising candidate for developing novel therapeutic interventions. Overall, GSK621 is a valuable tool for studying cellular energy regulation and holds promise as a potential therapeutic agent for various diseases.
Used in Pharmaceutical Industry:
GSK621 is used as a therapeutic agent for targeting cellular energy metabolism in the treatment of various diseases, including cancer and metabolic disorders. Its ability to inhibit AMPK activity leads to the suppression of cellular energy production and induction of cell death, making it a potential candidate for disrupting disease progression.
Used in Cancer Research:
GSK621 is used as a selective AMPK inhibitor for studying its potential therapeutic applications in cancer treatment. By disrupting cellular energy metabolism, GSK621 can suppress tumor growth and induce cell death, offering a promising approach for cancer therapy.
Used in Metabolic Disorder Research:
GSK621 is used as a modulator of cellular energy homeostasis for investigating its potential in treating metabolic disorders. Its ability to inhibit AMPK activity can help regulate energy production and consumption, providing a potential therapeutic strategy for managing metabolic imbalances.
Used in Inflammation and Immune Response Research:
GSK621 is used as a modulator of inflammation and immune responses for studying its potential in developing novel therapeutic interventions. Its effects on AMPK inhibition may contribute to regulating inflammatory processes and immune system function, offering new avenues for treating inflammatory and immune-related diseases.

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  • 6-chloro-5-{2'-hydroxy-3'-methoxy-[1,1'-biphenyl]-4-yl}-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4-dione

    Cas No: 1346607-05-3

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  • 1346607-05-3 Structure

  • Basic information

    1. Product Name: GSK621
    2. Synonyms: GSK621
    3. CAS NO:1346607-05-3
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1346607-05-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: GSK621(CAS DataBase Reference)
    10. NIST Chemistry Reference: GSK621(1346607-05-3)
    11. EPA Substance Registry System: GSK621(1346607-05-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1346607-05-3(Hazardous Substances Data)

1346607-05-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1346607-05-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,6,0 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1346607-05:
(9*1)+(8*3)+(7*4)+(6*6)+(5*6)+(4*0)+(3*7)+(2*0)+(1*5)=153
153 % 10 = 3
So 1346607-05-3 is a valid CAS Registry Number.

1346607-05-3Upstream product

1346607-05-3Downstream Products

1346607-05-3Relevant articles and documents

PYRROLO [3, 2 -D] PYRIMIDIN-3 -YL DERIVATIVES USED AS ACTIVATORS OF AMPK

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Page/Page column 68; 76, (2011/11/30)

The present invention relates to pyrrolopyrimidones compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.

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