134672-72-3

Basic information

• Product Name: Benzeneethanamine, 2,4-difluoro- (9CI)
• Synonyms: Benzeneethanamine, 2,4-difluoro- (9CI);2,4-Difluorophenethylamine97%;2,4-DIFLUOROPHENETHYLAMINE 97%;2-(2,4-Difluorophenyl)ethylamine;2,4-Difluoro-benzeneethanaMine;Benzeneethanamine,2,4-difluoro-
• CAS NO: 134672-72-3
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 157.1605664
• Product Categories: HALIDE
• Mol File: 134672-72-3.mol

Chemical Properties

• Boiling Point: 197℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.169
• PKA: 9.41±0.10(Predicted)
• CAS DataBase Reference: Benzeneethanamine, 2,4-difluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, 2,4-difluoro- (9CI)(134672-72-3)
• EPA Substance Registry System: Benzeneethanamine, 2,4-difluoro- (9CI)(134672-72-3)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 134672-72-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzeneethanamine, 2,4-difluoro(9CI) serves as a key intermediate in the synthesis of various pharmaceuticals. Its unique 2,4-difluoro substitution on the phenethylamine backbone provides specific properties that are beneficial for the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
Benzeneethanamine, 2,4-difluoro(9CI) is utilized as a versatile building block in organic synthesis, allowing for the creation of a wide range of organic compounds with diverse applications. Its 2,4-difluoro substitution on the phenethylamine backbone offers unique reactivity and selectivity in chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Chemical Research:
Benzeneethanamine, 2,4-difluoro(9CI) is employed in chemical research to explore the effects of fluorine substitution on the properties and reactivity of phenethylamines. Its unique structure provides insights into the influence of fluorine atoms on molecular interactions, stability, and biological activity, contributing to the advancement of chemical knowledge and the development of novel compounds with specific applications.

Upstream product

• 656-35-9 (2,4-difluorophenyl)acetonitrile 

Downstream Products

• 329314-69-4 N-tert-butoxycarbonylglycyl-N-(2,4-difluorophenylethyl)-2-methylalanine (N-cyclohex-1-enyl)amide 

Relevant articles and documents

Design and synthesis of N-nonpolar nucleobase dipeptides: Application of the Ugi reaction for the preparation of dipeptides havingfluoroarylalkyl groups appended to the nitrogen atom

A single-step one-pot synthesis based on the Ugi four-component condensation of previously unknown dipeptides, 2,3,4 and 5, having afluoroaromatic group appended to the nitrogen atom, is described. The series of dipeptides produced here can be viewed as nonpolar nucleobase dipeptides since the difluorotoluene nucleoside 1 is a well known nonpolar analogue of natural thymidine. A mixture of N-protected amino acids 7, fluorophenethylamines 6, isocyanides 8, and acetone or paraformaldehyde are stirred in methanol in the presence of 3 A molecular sieves to furnish the N-fluoroarylethyl-Aib- or -Gly-containing dipeptides 2 or 3, in moderate yields. The dipeptides 2d and 3b, having a cyclohex-1-enamide moiety, are deprotected readily with 3 M HCl in THF to a3ord the free dipeptides in high yields. The N-fluoroarylmethyl-Aib- or -Gly-containingβ-alanyl dipeptides 4 or 5, designed based on the structure of 2′,5′-linked isoDNA, are also synthesized in a similar fashion to the preparation of 2, in moderate to good yields as both protected and free dipeptides.

Novel nitrogen-containing titanocenes, and the use thereof

Titanocenes of the formula I STR1 in which R1 are cyclopentadienyl? groups and R2 and R3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by a pyrrylalkyl group, amidoalkyl group or imidoalkyl group, are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.