134700-29-1

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)- (9CI)
• Synonyms: 2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)- (9CI);5-propynyluracil;5-(1-propyn-1-yl)-2,4(1H,3H)-Pyrimidinedione
• CAS NO: 134700-29-1
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13474
• Product Categories: PYRIMIDINE
• Mol File: 134700-29-1.mol

Chemical Properties

• Appearance: /
• Density: 1.33 g/cm³
• Refractive Index: 1.585
• PKA: 7.72±0.10(Predicted)
• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)- (9CI)(134700-29-1)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)- (9CI)(134700-29-1)

Safety Data

• Hazardous Substances Data: 134700-29-1(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
2,4(1H,3H)-Pyrimidinedione, 5-(1-propynyl)(9CI) is used as a herbicide for controlling the growth of unwanted vegetation, such as weeds and grasses. It works by inhibiting the production of certain enzymes involved in plant growth, leading to their eventual death. This makes it an important tool in crop protection and weed management strategies.
However, it should be handled and applied with caution, as it can also have negative effects on non-target plant species and the environment.

InChI:InChI=1/C7H6N2O2/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,1H3,(H2,8,9,10,11)

Upstream product

• 51-20-7 5-bromouracil 
• 74-99-7 prop-1-yne 
• 696-07-1 5-iodouracil 

Downstream Products

• 700875-74-7 N-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-2-(2,4-dioxo-5-prop-1-ynyl-3,4-dihydro-2H-pyrimidin-1-yl)-N-({[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-acetamide 

Relevant articles and documents

The synthesis and antituberculosis activity of 5-alkynyl uracil derivatives

A series of new 5-alkynyl-substituted uracil and uridine derivatives were synthesised via palladium-catalysed Sonogashira cross-coupling reaction of 5-bromo-pyrimidine base with terminal acetylenes with good yields in DMF at room temperature. All obtained compounds were tested for antimycobacterial activity against Mycobacetrium bovis and Mycobacterium tuberculosis (H37Ra) at concentrations of 1–100 μg/ml using MABA test. Obtained results revealed that most of tested uracil derivatives exhibited high antimycobacterial activity (MIC50 = 1.1–19.2 μg/ml) in comparison with therapeutic agents such as rifampicin, isoniazid and D-cycloserine, excluding compounds having alkyl substituent at triple alkyne bond.

Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis

Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5′ nuclease digestion.

PNA-DNA chimeras containing 5-alkynyl-pyrimidine PNA units. Synthesis, binding properties, and enzymatic stability

Three chimeric dimer synthons (oeg_tNHT, oeg_upNHT and oeg_uhNHT) containing thymine (t), 5-(1-propynyl)-uracil (up) and 5-(1-hexyn-1-y1)-uracil (uh) PNA units with N-(2-hydroxyethyl)glycine (oeg) backbone were synthesized

Pharmaceutical compositions of 5-substituted uracil compounds

Pharmaceutical compositions containing 5-substituted uracil compounds are disclosed. The compositions are preferably in the form of a tablet or capsule.

Antiviral pyrimidine nucleosides

Pyrimidine 4'-thionucleosides of the formula I STR1 wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C2-6 alkyl, C2-6 alkenyl, C2-6 haloalkenyl or C2-6 alkynyl and physiologically functional derivatives thereof. These compounds have utility as anti-vital agents.

Preparation of thionucleosides

The invention relates to the preparation of homochiral thiolactones which have application in the synthesis of 3?- and 4?- thionucleosides. Substituents on the thiolactone can be used to influence the configuration of the C-1? position in the final nucleoside. Configuration at the C-4? position is controlled by use of the appropriate homochiral glycidol as starting material in the synthesis of the thiolactone. This process also offers the possibility of introducing substituents diastereoselectively in the C-2? and C-3? positions.