134742-26-0Relevant articles and documents
Synthesis and antitumor activities of water-soluble benzoylphenylureas
Okada, Hiroshi,Kato, Masanari,Koyanagi, Tohru,Mizuno, Kazuhiko
, p. 430 - 433 (2007/10/03)
Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.
Substituted benzoylurea compounds or their salts, processes for their production and antitumour compositions containing them
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, (2008/06/13)
A substituted benzoylurea compound of the formula (I): STR1 wherein R1 is a hydrogen atom, a halogen atom or a nitro group, each of R2 and R3 is a hydrogen atom, an alkyl group, --COR6 (wherein R6 is an alkyl group or an alkoxy group) or --SO2 R6 (wherein R6 is as defined above), or R2 and R3 may form together with the adjacent nitrogen atom a heterocyclic ring, R4 is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group or a nitro group, and R5 is a halogen atom, a nitro group or a substituted or unsubstituted alkyl group, or its salt.