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134762-03-1

(±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride is a naphthyridine carboxaldehyde derivative that exists as a hydrochloride salt. (±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride has demonstrated potential antineoplastic and antimalarial activities, making it a subject of interest for the development of treatments for cancer and malaria.

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  • 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carbaldehyde hydrochloride

    Cas No: 134762-03-1

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  • 134762-03-1 Structure

  • Basic information

    1. Product Name: (±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride
    2. Synonyms: A-71497; 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbaldehyde hydrochloride (1:1)
    3. CAS NO:134762-03-1
    4. Molecular Formula: C19H16ClF3N4O2
    5. Molecular Weight: 424.8041
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 134762-03-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 590.7°C at 760 mmHg
    3. Flash Point: 311.1°C
    4. Appearance: N/A
    5. Density: N/A
    6. Vapor Pressure: 6.26E-14mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: (±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride(134762-03-1)
    12. EPA Substance Registry System: (±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride(134762-03-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134762-03-1(Hazardous Substances Data)

134762-03-1 Usage

Uses

Used in Pharmaceutical Industry:
(±)-7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxaldehyde hydrochloride is used as a potential therapeutic agent for the treatment of cancer. It operates by inhibiting the enzyme topoisomerase II, which is crucial for DNA replication, thereby disrupting the proliferation of cancer cells.
Additionally, this compound is used as a potential therapeutic agent for the treatment of malaria. It has shown promise in interfering with the life cycle of the malaria parasite, offering a new avenue for combating this widespread disease.
Further research is being conducted to fully explore the therapeutic potential of this compound, with the aim of developing it into an effective drug for the treatment of these serious health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 134762-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,7,6 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 134762-03:
(8*1)+(7*3)+(6*4)+(5*7)+(4*6)+(3*2)+(2*0)+(1*3)=121
121 % 10 = 1
So 134762-03-1 is a valid CAS Registry Number.

134762-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carbaldehyde,hydrochloride

1.2 Other means of identification

Product number -
Other names 1,8-Naphthyridine-3-carboxaldehyde,7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-,monohydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134762-03-1 SDS

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