- Pyrazine derivatives and its preparation and pharmaceutical composition and use thereof (by machine translation)
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The invention discloses a new class of pyrazine derivatives, and its preparation and pharmaceutical composition and use. Specifically, relates to the general formula I and II shown in the pyrazine derivative, a pharmaceutically acceptable salt thereof, and its preparation method, comprising one or more of the compounds of the composition, and the compound in treating mitochondrial function disorders related diseases such as the metabolic syndrome, neurodegenerative diseases, aging, the ischemia reperfusion, use of cancer and other diseases. (by machine translation)
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Paragraph 0139; 0143; 0144
(2019/01/04)
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- Separation of 2,3-diamino-dihalopyrazines from mixtures as novel association products with certain ketones
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Insoluble association products are formed when solid 2,3-diamino-5,6-dihalopyrazines are contacted with liquid ketones of the structure R1 --CH2 --CO--CH2 --R2, wherein R1 and R2 are both H or together constitute a polymethylene chain of from 2 to 4 carbons. The isomeric 2,6-diamino-dihalopyrazines dissolve in the ketones. Thus, mixtures of the solid 2,3-diamino-dihalopyrazines with their isomers and/or other ketone-soluble materials can be resolved by contacting the mixtures with ketones of the preceding structure and separating the resultant solid and liquid phases. The association products constitute a novel composition of matter.
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