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2-methyl-4-(tributylstannyl)pyridine is an organotin compound characterized by the presence of a pyridine ring with a methyl and tributylstannyl group attached. 2-methyl-4-(tributylstannyl)pyridine is recognized for its role in organic synthesis, especially in the functionalization of aromatic compounds, where the tributylstannyl group acts as a versatile leaving group, facilitating the introduction of new functional groups onto the pyridine ring.

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  • 134914-97-9 Structure
  • Basic information

    1. Product Name: 2-Methyl-4-(tributylstannyl)pyridine
    2. Synonyms: 2-Methyl-4-(tributylstannyl)pyridine;Tributyl-(2-MethylpyridiN-4-Yl)Stannane
    3. CAS NO:134914-97-9
    4. Molecular Formula: C18H33NSn
    5. Molecular Weight: 382.17132
    6. EINECS: N/A
    7. Product Categories: Stannanes
    8. Mol File: 134914-97-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 391.9°C at 760 mmHg
    3. Flash Point: 190.8°C
    4. Appearance: /
    5. Density: N/A
    6. Vapor Pressure: 5.39E-06mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-Methyl-4-(tributylstannyl)pyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Methyl-4-(tributylstannyl)pyridine(134914-97-9)
    12. EPA Substance Registry System: 2-Methyl-4-(tributylstannyl)pyridine(134914-97-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134914-97-9(Hazardous Substances Data)

134914-97-9 Usage

Uses

Used in Organic Synthesis:
2-methyl-4-(tributylstannyl)pyridine is used as a reagent for the functionalization of aromatic compounds, leveraging the tributylstannyl group as a useful leaving group in various reactions, which allows for the attachment of new functional groups onto the pyridine ring.
Used in Preparation of Organometallic Reagents:
2-methyl-4-(tributylstannyl)pyridine is utilized in the preparation of organometallic reagents, which are essential in various chemical reactions and processes, contributing to the advancement of synthetic chemistry.
Used in Pharmaceutical and Agrochemical Synthesis:
2-methyl-4-(tributylstannyl)pyridine is employed in the synthesis of pharmaceuticals and agrochemicals, where its unique structure and reactivity contribute to the development of new and effective compounds for medical and agricultural applications.
However, it is important to note that due to the toxic properties associated with the tributylstannyl group, the use of 2-methyl-4-(tributylstannyl)pyridine is restricted in certain applications to ensure safety and environmental considerations.

Check Digit Verification of cas no

The CAS Registry Mumber 134914-97-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,9,1 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 134914-97:
(8*1)+(7*3)+(6*4)+(5*9)+(4*1)+(3*4)+(2*9)+(1*7)=139
139 % 10 = 9
So 134914-97-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N.3C4H9.Sn/c1-6-4-2-3-5-7-6;3*1-3-4-2;/h3-5H,1H3;3*1,3-4H2,2H3;/rC18H33NSn/c1-5-8-13-20(14-9-6-2,15-10-7-3)18-11-12-19-17(4)16-18/h11-12,16H,5-10,13-15H2,1-4H3

134914-97-9 Well-known Company Product Price

  • Brand
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  • Aldrich

  • (SYX00061)  2-Methyl-4-(tributylstannyl)pyridine  AldrichCPR

  • 134914-97-9

  • SYX00061-1G

  • 3,540.42CNY

  • Detail

134914-97-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tributyl-(2-methylpyridin-4-yl)stannane

1.2 Other means of identification

Product number -
Other names (2-Methylpyridin-4-yl)tributyltin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134914-97-9 SDS

134914-97-9Relevant articles and documents

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

Xu, Zhixiang,Li, Jiajun,Wu, Yiyuan,Sun, Zhijian,Luo, Lusong,Hu, Zhilin,He, Sudan,Zheng, Jiyue,Zhang, Hongjian,Zhang, Xiaohu

, p. 154 - 165 (2015/12/04)

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases

-

Page/Page column 16, (2012/05/21)

The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases.

NOVEL SULFONYL DERIVATIVES

-

, (2008/06/13)

Sulfonyl derivatives represented by the following general formula (I): Q1-Q2-T1-Q3-SO2-QA and drugs containing the same (wherein Q1 is an optionally substituted, saturated or unsaturated, five- or six-membered cyclic hydrocarbon group, a five- or six-membered heterocyclic group, or the like; Q2 is a single band, oxygen, sulfur, C1-C6 alkylene or the like; QA is optionally substituted arylalkenyl, heteroarylalkenyl or the like; and T1 is carbonyl or the like). These compounds have potent FXa-inhibitory effects and promptly exert satisfactory and persistent antithrombotic effects through oral administration, thus being useful as anticoagulant agents little accompanied with side effects.

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