- Reaction of N-Substituted Cyclic Amines with 2,4-Dichloroquinazoline, 2,4-Dichloropyrimidine, and its 5-Methyl Derivative
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The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline 2 and 2,4-dichloro-5-methyl-pyrimidine 3b afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively.However, the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines.The regioselectivity of these reactions was considered to be determined by the steric nature of substrates 2, 3a and 3b.
- Yoshida, Kenji,Taguchi, Masahiro
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p. 919 - 922
(2007/10/02)
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- Reaction of Quinazoline-2,4(1H,3H)-dione with N-Substituted Cyclic Amines in Combination with Phosphoryl Trichloride
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The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines.In the case of N-s
- Yoshida, Kenji,Tanaka, Takashi,Ohtaka, Hiroshi
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p. 1279 - 1282
(2007/10/02)
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