134961-18-5

Basic information

• Product Name: 2-(azepan-1-yl)-4-chloroquinazoline
• Synonyms: 2-(azepan-1-yl)-4-chloroquinazoline
• CAS NO: 134961-18-5
• Molecular Formula: C14H16ClN3
• Molecular Weight: 262
• Mol File: 134961-18-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(azepan-1-yl)-4-chloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(azepan-1-yl)-4-chloroquinazoline(134961-18-5)
• EPA Substance Registry System: 2-(azepan-1-yl)-4-chloroquinazoline(134961-18-5)

Safety Data

• Hazardous Substances Data: 134961-18-5(Hazardous Substances Data)

Usage

Heterocyclic compound

quinazoline and azepane rings The compound consists of two heterocyclic rings, which are rings containing both carbon and nitrogen atoms, contributing to its complex structure and potential biological activity.

Potential applications

Medicinal chemistry 2-(azepan-1-yl)-4-chloroquinazoline has potential uses in the field of medicinal chemistry, particularly in the development of pharmaceutical drugs.

4-chloro substituent

Specific properties and activities The presence of the 4-chloro group on the quinazoline ring can provide specific properties and activities to the compound, making it potentially useful in treating certain diseases or conditions.

Therapeutic uses

Further research and studies Additional research and studies on 2-(azepan-1-yl)-4-chloroquinazoline may reveal its potential therapeutic uses and benefits in the field of medicine, contributing to the development of new drugs and treatments.

Upstream product

• 1192-95-6 hexahydro-1-methyl-1H-azepine 
• 607-68-1 2,4-dichloroquinazoline 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 53678-65-2 N-allylhexamethyleneimine 
• 20422-13-3 1-benzylazepane 

Relevant articles and documents

Reaction of N-Substituted Cyclic Amines with 2,4-Dichloroquinazoline, 2,4-Dichloropyrimidine, and its 5-Methyl Derivative

The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline 2 and 2,4-dichloro-5-methyl-pyrimidine 3b afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively.However, the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines.The regioselectivity of these reactions was considered to be determined by the steric nature of substrates 2, 3a and 3b.

Reaction of Quinazoline-2,4(1H,3H)-dione with N-Substituted Cyclic Amines in Combination with Phosphoryl Trichloride

The reaction of quinazoline-2,4(1H,3H)-dione with N-allyl, N-benzyl and N-methyl cyclic amines in combination with phosphoryl trichloride in the presence of tripropylamine in 1,4-dioxane afforded 4-chloro-2-(cycloalkylamino)quinazolines.In the case of N-s