An asymmetric synthesis of a 3-hydroxy-β-lactam by keteneimine cycloaddition: Utilization of chiral ketenes from carbohydrates
The Staudinger reaction of a chiral carbohydrate-based ketene and an imine proceeds to give, after removal of the sugar, cis-3-hydroxy-β-lactam 7 in moderate yield with good asymmetric induction (70% e.e.).
Borer, Bennett C.,Balogh, Douglas W.
p. 1039 - 1040
(2007/10/02)
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