- Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists
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A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed imp
- Liu, Weiguo,Hussain, Zahid,Zang, Yi,Sweis, Ramzi F.,Romero, F. Anthony,Finke, Paul E.,Moningka, Remond,Bao, Jianming,Plotkin, Michael A.,Shang, Jin,Dingley, Karen H.,Salituro, Gino,Murphy, Beth Ann,Howard, Andrew D.,Ujjainwalla, Feroze,Wood, Harold B.,Duffy, Joseph L.
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p. 1088 - 1093
(2018/10/24)
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- SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS
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Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
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