- A [...][...] synthetic method
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The invention relates to a synthetic method for gizzerosine and belongs to the technical field of medicines. According to the synthetic method provided by the invention, the steric hindrance of an end amino of lysine is different from that of an alpha-site amino, directly reacts with 4-(2-chloroethyl) imidazole to synthesize a target product through three-step reactions: histamine hydrochloride hydroxylation , chloro reaction and condensation. The method is simple and fast, is suitable for large-scale synthesis, and can be widely applied to related scientific research fields such as toxicology and metabolic experiments.
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Paragraph 0028; 0109; 0110; 0117; 0124
(2018/06/14)
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- Poly(4-vinylimidazolium)s/diazabicyclo[5.4.0]undec-7-ene/zinc(II) bromide-catalyzed cycloaddition of carbon dioxide to epoxides
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Poly(4-vinylimidazolium)s, derived from the self-immobilization of 4-vinylimidazoliums, with diazabicyclo[5.4.0]undec-7-ene (DBU) and zinc bromide (ZnBr2) are used as a highly efficient catalyst for the chemical fixation of carbon dioxide. This catalytic system has been applied for the preparation of cyclic carbonates from terminal epoxides and carbon dioxide. Many functional groups, including chloro, vinyl, ether, and hydroxy groups are well tolerated in the reactions. Moreover, the catalytic system was found to catalyze the conversion of more sterically congested epoxides which are generally considered to be challenging substrates for fabricating the cyclic organic carbonates. In addition, the disubstituted epoxides are found to react with retention of configuration. The polymer precatalyst is easily recovered and reused. A plausible reaction mechanism is proposed.
- Seo, Ue Ryung,Chung, Young Keun
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supporting information
p. 1955 - 1961
(2014/07/07)
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- Poly(4-vinylimidazolium) iodides: A highly recyclable organocatalyst precursor for benzoin condensation reaction
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The development of highly efficient, recyclable poly(4-vinylimidazolium) iodides (2) for the benzoin condensation reaction under mild reaction conditions is discussed: poly(4-vinyl N-heterocyclic carbene)s (3) obtained from 2 showed higher catalytic activity than monomeric 4-vinyl N-heterocyclic carbene and could be successfully recovered and reused over seven times without loss of performance. the Partner Organisations 2014.
- Seo, Ue Ryung,Chung, Young Keun
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p. 32371 - 32374
(2014/08/18)
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